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This suggests that PLC- levels are strongly correlated with poor prognosis of breast cancer ( 3.3 PI(4,5)P2/Cofilin The migration of tumor cells is the key step to complete the metastasis, and phosphatidylinositol-4,5-diphosphate (PI(4,5)P2) has been proved to be an important regulator of tumor cell migration, which affects the movement ability of cells by regulating actin ( 3.4 PABPC1-PI3K-AKT pathway Cholangiocarcinoma (CAA) is an epithelial malignant tumor originating from bile duct